Comparing Oral vs. Injectable Semaglutide for Weight Loss

As more New Zealanders explore medical options for managing obesity, semaglutide has become a widely discussed tool. Originally developed to treat type 2 diabetes, this GLP-1 receptor agonist is now approved and used for effective weight loss — helping to regulate appetite, reduce cravings, and support long-term lifestyle change.

Semaglutide is available in both oral and injectable forms, but which one is right for you? This guide explores the key differences, benefits, and considerations to help you make an informed decision — with support from Pocket Lab’s Weight Loss Care Plan.

What is Semaglutide?

Semaglutide is part of a class of medications that mimic a natural hormone (GLP-1) which helps regulate blood sugar and appetite. It works by:

• Slowing down digestion

• Increasing feelings of fullness

• Reducing appetite and cravings

• Helping with weight reduction when combined with lifestyle changes

It is available in weekly injectable formulations (like Wegovy) and daily oral tablets (available under other brand names overseas).

Oral Semaglutide: What You Should Know

Oral semaglutide is taken once daily and offers a needle-free option for patients who prefer tablets over injections.

Pros:

• No injections or devices required

• May suit those with needle anxiety

• Convenient for daily routines

Cons:

• Must be taken first thing in the morning on an empty stomach

• Requires timing your meals and other medications carefully

• Not currently available in NZ

• Daily dosing may be harder to maintain consistently

Injectable Semaglutide (e.g. Wegovy)

Injectable semaglutide is typically administered once a week using a pre-filled pen. In New Zealand, Wegovy is the most well-known injectable GLP-1 for weight loss.

Pros:

• Only one injection per week

• More stable blood levels due to weekly dosing

• Globally recognised for its strong clinical weight loss results

• Less daily routine disruption

Cons:

• Requires injection (usually into the abdomen or thigh)

• May cause mild injection-site reactions

• Some people may feel nervous using the pen initially

Effectiveness: Is One Better Than the Other?

Both oral and injectable semaglutide have been shown to support weight loss in clinical trials — particularly when paired with nutritional guidance and behaviour change.

That said, injectable semaglutide (Wegovy) is generally considered more effective for weight loss outcomes. This is due to:

• Higher doses possible with injectable forms

• More consistent absorption

• Fewer requirements around food timing

Clinical studies suggest people using injectable semaglutide may lose 10–15% of their body weight over time with proper support. While oral semaglutide is still promising, its effect may be slightly reduced depending on adherence and timing.

Safety and Side Effects

Both forms share similar side effects, including:

• Nausea

• Constipation or diarrhoea

• Fatigue

• Loss of appetite

These symptoms usually ease after a few weeks. A slow and guided dose increase can reduce discomfort. Pocket Lab’s Weight Loss Care Plan includes GP support to monitor your progress and adjust as needed.

Which One is Right for You?

Choosing between oral and injectable semaglutide depends on your lifestyle, medical history, and preferences.

You might prefer oral if:

• You strongly dislike needles

• You’re able to follow strict timing around food and other medications

You might benefit more from injectable if:

• You want a convenient once-weekly option

• You prefer a simpler routine with fewer timing restrictions

• You're looking for the most effective weight loss support currently available

Pocket Lab Makes It Easy to Get Started

Whether you’re considering oral or injectable semaglutide, Pocket Lab connects you with a New Zealand-registered GP to assess your needs and prescribe weight loss medication if appropriate. Our fully virtual Weight Loss Care Plan includes:

• Personalised GP assessment

• Medication options like Wegovy

• Ongoing virtual check-ins

• Nutrition and lifestyle guidance

Final Thoughts

Both oral and injectable forms of semaglutide have the potential to support your weight loss journey — but understanding the differences can help you commit to a plan that suits your life. If you're unsure where to start, talk to one of our online GPs at Pocket Lab. We’re here to guide you toward safe, effective, and sustainable results.